Protocol #3: Fatty Liver
The human body’s largest internal organ is the liver. This vital organ is responsible for processing everything we eat and drink and filtering harmful substances such as toxins and poisons from the blood. Too much fat in the liver can lead to long-term liver damage. In many cases, fatty liver has no symptoms yet it becomes more harmful as the condition progresses.
Fatty liver occurs when excess fat accumulates inside liver cells. This means normal, healthy liver tissue becomes partly replaced with fatty tissue. Fatty liver is now recognised as the most common cause of abnormal liver function test results in the USA, UK and Australia. Around one in five people in the general population, in the USA and Australia have a fatty liver. Fatty liver is usually associated with abdominal obesity, insulin resistance and type 2 diabetes. If severe, it can eventually lead to cirrhosis and liver failure.
The most commonly recognized cause of fatty liver is related to heavy alcohol drinking, certain drugs and eating processed junk foods. If alcohol is the cause, the fat can disappear, usually within 6 weeks, when people stop drinking.
However, if the cause is not identified and corrected, fatty liver can have serious consequences. For example, if people continue to drink large amounts of alcohol or if the processed foods and a drug causing fatty liver is not stopped; repeated liver injury may eventually lead to cirrhosis or other consequences.
There are now many researchers who believe that metabolic syndrome (a group of disorders that increase the risk of diabetes, heart disease and stroke) plays an important role in the development of fatty liver. Excess body weight, a diet high in processed sugar, high triglycerides, diabetes, and lack of physical activity, all play a role in liver health.
High Fructose Corn Syrup is VERY TOXIC to the Liver It is now revealed to be directly related to all non-alcoholic fatty liver disease.
If you want to heal your liver, one of the best things you can do is to clean up your diet (cut out excessive sugars, processed foods and detrimental pharmaceuticals), incorporate raw fruits and vegetables, avoid breads and grains, avoid alcohol and get daily exercise. The biggest offenders are processed sugars and foods made of white flour.
However, a high intake of carbohydrate rich foods in general can promote fatty liver, as the liver converts excess carbohydrate into fat. Foods that need to be restricted include bread, pasta, rice, breakfast cereals, potatoes and any food made of flour. Most vegetable oil and margarines can worsen a fatty liver. Healthy fats to include more of in your diet are found in olive oil, oily fish, flaxseeds, coconut oil and raw nuts and seeds.
BluZone
Methylene blue (MB) has many benefits to the health of the liver. It has been found to reverse fatty liver and hypoxia related to cirrhosis of liver.
The following research is from Ray Peat’s educational forum: (steatosis is fatty liver and steatohepatitis is inflammation of the liver).
"...In mice fed on a high-fat diet for 8 weeks, MB treatment inhibited excessive hepatic fat accumulation and steatohepatitis. The ability of MB to activate SIRT1 promotes mitochondrial biogenesis and oxygen consumption and activates AMPK, contributing to anti-lipogenesis in the liver. Our results provide new information on the potential use of MB for the treatment of steatosis and steatohepatitis."
Studies done with mice using MB to treat fatty liver were so positive that human studies are now being explored.
The human equivalent doses were 0.2mg/kg and 0.6mg/kg (in reference; 0.6mg/kg is equivalent to the Daily Maintenance Protocol for BluZone). The duration of the study was 4 weeks and methylene blue reversed the fatty liver parameters back to normal.
AgeLess C60
Carbon 60 (C60). The effectiveness of C60 to protect cells from degradation is beyond anything known to date and really cannot be compared to vitamin C or any other antioxidant free radical scavenger. C60 even neutralizes normally lethal doses of hepatotoxins (a toxic chemical substance that damages the liver) as demonstrated in the famous rat longevity study conducted in France.
C60 has been shown to help heal fatty liver through its protective action against reactive oxygen species (ROS), which has led many researchers to hypothesize that it may yield a fat management effect, based on the assumption that reactive oxygen species play a key factor in the development of obesity.
A study published by Molecular and Cellular Biochemistry examined intracellular lipid accumulation in a laboratory mouse model and observed C60’s ability to suppress this process. Researchers found that C60 suppressed lipid accumulation and subsequent PPARγ2 expression, ultimately decreasing the spontaneous differentiation of preadipocytes into adipocytes (or fat storage cells).
A 2010 study published by Biomaterials yielded similar results. Researchers explored the effects of C60 on adipose conversion in inflammatory adipose-tissue and stromal preadipocyte-U937 lymphoma cell cultures. They found that C60 inhibited macrophage activation and adipogenesis in the OP9-U937 culture. Researchers concluded that C60 may have potential as a therapeutic option in the treatment of metabolic syndrome and/or obesity-related diseases.
Super AGC
Super Activated Gold Curcumin can be helpful for liver repair. Several studies suggest that curcumin (the active medicinal compound in turmeric), plays a role in treating nonalcoholic fatty liver disease (NAFLD). Curcumin can help reduce inflammation, a key symptom of NAFLD.
In a 2021 study Trusted Source, 64 people with NAFLD took either 2 grams of turmeric or a placebo every day for 8 weeks. Liver enzymes dropped significantly in the turmeric group. Liver enzymes tend to climb with NAFLD. Serum levels of triglycerides and cholesterol also declined in the turmeric group. The placebo group did not show similar changes.
Daily Protocol
1. BluZone:This can be taken anytime; we find one dose in the morning completely adequate. MB is water-soluble so you don’t need to take it with a meal, or healthy fat like some nootropics. Simply add the drops to water or juice.
There are two protocols for using BluZone. Our recommendation is to start with a low dose (Daily Maintenance) and see how you react. Allow a week on the daily maintenance before engaging the Loading Protocol.
Directions: Shake before each use. Add drops to water or juice
Daily Maintenance Protocol: 1 drop for every 4kg of body weight (bodyweight divided by 4)
Loading Protocol: 1 drop for every 2kg of body weight for 2 weeks then drop back to the daily maintenance. (Bodyweight divided by 2)
2. AgeLess C60: This can be taken anytime; we find one dose in the morning completely adequate.
Our recommended dose is 2.5 ml/day (1/2 tsp) if under 65kg and 5ml (1 tsp) if over 65 kg
3. Super AGC: Curcumin is considered a food supplement; as such specific dosing has not been determined. We find that 1-2 tsp daily provides a good therapeutic effect.
One of our favourite ways to use Super AGC: Activated Gold Curcumin is in a tea, “liquid gold”. It has a lovely mild spicy flavour and seems to provide an immediate energy boost. Spice up main dishes such as chicken, turkey, rice, vegetables, beans, and soups. Add it to salad dressings, marinades, glazes, potatoes, smoothies, bone broth, eggs, and sautéed onions.
Directions: Add 1/4 -1/2 tsp in a cup of hot (not boiling) pure water. A bit of honey can be added (optional). It can also be added to hot coconut milk if you prefer a curcumin latte.
For a refreshing iced tea: Add 1/4 -1/2 tsp in a glass of water with a squeeze of lemon, pinch of cayenne pepper and a dab of real maple syrup.